iBiomagazine

Description: Recombinant Human Transformer 2 Beta expressed in: E.coli

Description: A sandwich ELISA kit for detection of Transformer 2 Beta from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: Recombinant Human Transformer-2 protein homolog beta(TRA2B) expressed in Baculovirus

Description: Recombinant Human Transformer-2 protein homolog beta(TRA2B),partial expressed in E.coli

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b)

Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Description: Quantitative sandwich ELISA for measuring Human Transformer-2 protein homolog beta (TRA2B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Transformer-2 protein homolog beta (TRA2B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Transformer-2 protein homolog beta (TRA2B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human Transformer 2 Beta (TRA2b). This antibody is labeled with APC-Cy7.

Description: Recombinant protein for human Transformer-2 protein homolog beta

Description: Description of target: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.4 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.8"Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing."_x005F_x005F_x000D_Tacke R., Tohyama M., Ogawa S., Manley J.L._x005F_x005F_x000D_Cell 93:139-148(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.Ref.11"hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1."_x005F_x005F_x000D_Hofmann Y., Wirth B._x005F_x005F_x000D_Hum. Mol. Genet. 11:2037-2049(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH RBMX, RNA-BINDING.Ref.12"HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding."_x005F_x005F_x000D_Nasim M.T., Chernova T.K., Chowdhury H.M., Yue B.G., Eperon I.C._x005F_x005F_x000D_Hum. Mol. Genet. 12:1337-1348(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, RNA-BINDING.Ref.13"Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors."_x005F_x005F_x000D_Wang J., Gao Q.S., Wang Y., Lafyatis R., Stamm S., Andreadis A._x005F_x005F_x000D_J. Neurochem. 88:1078-1090(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.057 ng/mL

Description: Mouse polyclonal to TRA2B

Description: The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
* Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.